Heparin-induced thrombocytopenia and thrombosis

Heparin induced thrombocytopenia

Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...

Plasmapheresis in heparin-induced thrombocytopenia and thrombosis.

To the Editor: Thrombosis associated with severe thrombocytopenia is an infrequent, but life-threatening side effect of heparin therapy, which can involve any venous or arterial territory including the cerebral circulation. The treatment of this serious complication has not been satisfactorily resolved. Recently, Becker and Miller reviewed heparin-induced thrombocytopenia with thromboembolism a...

How I treat heparin-induced thrombocytopenia and thrombosis.

Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment.

Heparin induced thrombocytopenia thrombosis (HIT/T) is associated with a high morbidity and mortality. Diagnosis is essentially clinical and negative results of laboratory assays do not exclude the diagnosis. Treatment involves stopping all heparin immediately and giving an alternative thrombin inhibitor. The adoption of low molecular weight heparins is one reason for the reduced incidence of t...

Antibodies From Patients With Heparin-Induced Thrombocytopenia/Thrombosis

Antibodies associated with heparin-induced thrombocytopenia/thrombosis (HITT) are now thought to be specific for complexes formed between heparin and platelet factor 4 (PF4), a basic protein found normally in platelet alpha granules. How these antibodies cause thrombocytopenia and, in some patients, thrombosis, is not fully understood, in part because purified antibodies that could be labeled a...